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  "Title": "Dose-Response Relationship Analysis of Nanomaterial Toxicity",
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  "Authors@R": "c(person(given = \"Rahmasari Nur\",\nfamily = \"Azizah\",\nrole = c(\"aut\",\"cre\"),\nemail = \"rahma.azizah@uhasselt.be\"),\nperson(given = \"Geert\",\nfamily = \"Verheyen\",\nrole = c(\"aut\",\"ths\"),\nemail = \"geert.verheyen@thomasmore.be\"),\nperson(given = \"Sabine\",\nfamily = \"Van Miert\",\nrole = c(\"aut\",\"ths\"),\nemail = \"sabine.vanmiert@thomasmore.be\"),\nperson(given = \"Ziv\",\nfamily = \"Shkedy\",\nrole = c(\"aut\",\"ths\"),\nemail = \"ziv.shkedy@uhasselt.be\"))",
  "Maintainer": "Rahmasari Nur Azizah <rahma.azizah@uhasselt.be>",
  "Description": "Perform an exploration and a preliminary analysis on the\ndose- response relationship of nanomaterial toxicity. Several\nfunctions are provided for data exploration, including\nfunctions for creating a subset of dataset, frequency tables\nand plots. Inference for order restricted dose- response data\nis performed by testing the significance of monotonic\ndose-response relationship, using Williams, Marcus, M, Modified\nM and Likelihood ratio tests. Several methods of multiplicity\nadjustment are also provided. Description of the methods can be\nfound in\n<https://github.com/rahmasarina/dose-response-analysis/blob/main/Methodology.pdf>.",
  "License": "GPL-3",
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  "Author": "Rahmasari Nur Azizah [aut, cre], Geert Verheyen [aut, ths],\nSabine Van Miert [aut, ths], Ziv Shkedy [aut, ths]",
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  "Date/Publication": "2022-09-01 14:20:05 UTC",
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  "_created": "2026-10-24T07:42:54.000Z",
  "_published": "2026-10-24T07:46:55.655Z",
  "_upstream": "https://github.com/cran/NMTox",
  "_status": "success",
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      "title": "Genetic toxicity in vitro dataset",
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        "tbl",
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        "publicname",
        "supplier",
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        "method",
        "studyprovider",
        "endpoint",
        "value",
        "unit",
        "celltype",
        "treatment",
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        "exptime",
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        "concentration",
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      "table": true,
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  "_help": [
    {
      "page": "adjPlot",
      "title": "Plot the adjusted p-values, raw p-values and FDR level",
      "topics": [
        "adjPlot"
      ]
    },
    {
      "page": "FrCtrl",
      "title": "Create a frequency table of the control values",
      "topics": [
        "FrCtrl"
      ]
    },
    {
      "page": "Frtab",
      "title": "Generate the number of unique values, the list of unique values, or the number of observations of specified variable(s)",
      "topics": [
        "Frtab"
      ]
    },
    {
      "page": "Frtab.sub",
      "title": "Count the number of observations for each unique value of a variable on a subset of data",
      "topics": [
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      ]
    },
    {
      "page": "geninvitro",
      "title": "Genetic toxicity in vitro dataset",
      "topics": [
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    },
    {
      "page": "Isoplot",
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      "topics": [
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      ]
    },
    {
      "page": "IsoPlot.nm",
      "title": "Create a plot of the observations, sample means and fitted isotonic regression curve for one nanomaterial",
      "topics": [
        "IsoPlot.nm"
      ]
    },
    {
      "page": "IsoPval.nm",
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      "topics": [
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      ]
    },
    {
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      "title": "Calculate the test statistics and p-values for testing monotonic trend",
      "topics": [
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    },
    {
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      "title": "Calculate the value of the test statistics for testing monotonic trend",
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      ]
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    },
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